As physicians, we have all cared for patients with moderate to severe allergies and/or asthma who suffer through exacerbations of their symptoms time and time again. Many of these patients could benefit from immunotherapy, a most effective method of treatment for allergies. However, immunotherapy requires a significant commitment. Many patients are unwilling to make this commitment due to the understandable intolerance of numerous injections or the inconvenience of scheduling regular injections for many years. Yet, many of these patients are committed to good health and treating their allergies.

The board certified allergists of Allergy & Asthma Specialtists are now pleased to offer this alternative form of highly effective, yet convenient immunotherapy. Sublingual immunotherapy is an injection-free procedure.

As physicians, we hope to offer this alternative form of immunotherapy to those patients who could benefit. Our goal is to serve as consultants in providing sublingual immununotherapy and refer patients back to their primary care physicians or specialists for follow up care.

• Has been used for over sixty years in Europe.
• Nearly half of the immunotherapy administered in Europe is sublingual.
• Endorsed by the World Health Organization as an effective alternative to subcutaneous immunotherapy.
• Studies indicate that sublingual immunotherapy is very effective.
• There has never been a reported case of anaphylaxis while using sublingual immunotherapy.

• Passalacqua, G, Canonica, GW, "Sublingual or injection immunotherapy: the final answer?" Allergy 2004: 59: 37-38.
• Malling, Hans-Jorgen "Comparison of the clinical efficacy and safety of subcutaneous and sublingual immunotherapy: methodological approaches and experimental results," Current Opinion in Allergy and Clinical Immunology, Vol. 4, pgs. 539-542, 2004.
• Bousquet, J "Sublingual immunotherapy: from proven prevention to putative rapid relief of allergic symptoms," Editorial , Allergy, Vol. 60, Issue pgs. 1-3, January 2005.
• Passalacqua, Giovanni, et al "Efficacy and safety of sublingual immunotherapy," Annals of Allergy, Asthma, and Immunology, Vol. 93; 1, pgs. 3-12, 2004.
• Malling, Hans-Jorgen "Comparison of the clinical efficacy and safety of subcutaneous and sublingual immunotherapy: methodological approaches and experimental results," Current Opinion in Allergy and Clinical Immunology, Vol. 4, pgs. 539-542, 2004.
• Di Rienzo, V., Canonica, GW, and Passalacqua G. "Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10 year prospective study," Clinical and Experimental Allergy, Vol. 33, pgs. 206-210, 2003.
• Carlos E. Baena-Cagnani, Giovanni Passalacqua, Rodrigo C. Baena-Cagnani, Victor H. Croce and Walter G. Canonica: "Sublingual immunotherapy in pediatric patients: beyond clinical efficacy." Curr Opin Allergy Clin Immunol, 5: 173-177. 2005 Lippincott Williams & Wilkins.
• Markert, UR and Elsner P. Local Immunotherapy in Allergy, Chemical Immunology and Allergy (lead chapter by D. Morris, et al) Vol. 82, Karger, Basel, Switzerland 2003.
• Novembre, E. et al "Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis," Journal Allergy and Clinical Immunology, Vol. 114, No. 4, pgs. 851-857, October 2004.
• Pajno, G.B. et al, "Impact of Sublingual Immunotherapy on Seasonal Asthma of Allergic Children to Parietaria Pollen Treated with Inhaled Fluticasone Propionate," Journal Allergy Clinical Immunology, Vol. 109, No. 1, pg. S200, January 2002.
• Khinch, Malling et.al., "Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: a randomized, placebo-controlled, double-blind, double-dummy study," Allergy, 2004: 59: 45-53.

• Nelson, Harold "Advances in upper airway diseases and allergen immunotherapy," Journal of Allergy and Clinical Immunology, Vol. 113, No. 4, Pages 635-42, April 2004.
• Portnoy J. "Allergen Immunotherapy in the Prevention of Asthma" Current Opinion Allergy Clinical Immunology 4 (2): 131-136, 2004.